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SOX11: drugging opportunities ahead

The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor…
Sarah-Lee Bekaert
23 March 2023
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Check out our new paper at Cancers MDPI

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation. Our discovery efforts focused on identifying cooperating interactors and vulnerabilities in the MYCN regulatory network. MYCN-driven neuroblastomas can…
Sarah-Lee Bekaert
5 October 2021